Evaluation of Positive Inotropic Activity Induced bya Danazol Derivative in Isolated Rat Heart Model
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چکیده
منابع مشابه
Evaluation of Positive Inotropic Activity Induced bya Danazol Derivative in Isolated Rat Heart Model
There is scarce information about the effects of danazol and its derivatives at cardiovascular level. In addition, to date the cellular site and mechanism of action of danazol at the cardiovascular level is very confusing. In order to clarify those phenomena in this study, a danazol derivative was synthesized with the objective of evaluating its activity on perfusion pressure and coronary resis...
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There are some reports which indicate that several triazole derivatives have inotropic activity; however, the cellular site and mechanism of action at cardiovascular level is very confusing. In order, to have a clear understanding of these phenomena, a triazole derivative was synthesized to evaluate its biological activity on left ventricular pressure and characterize the molecular mechanism. T...
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Experimental studies suggest that danazol can be associated with changes in blood pressure. Nevertheless, there is scarce information about the effects of danazol and its derivatives at cardiovascular level. To clarify on this phenomenon, we evaluated the effects of danazol derivative on perfusion pressure in isolated rat heart using Langendorff flow model. Our results demonstrated that pregnen...
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ژورنال
عنوان ژورنال: Pharmacology & Pharmacy
سال: 2013
ISSN: 2157-9423,2157-9431
DOI: 10.4236/pp.2013.44058